Van de Ven Double Halts Everton's Run at New Stadium
The Dutch defender became the initial defender to score twice in a Premier League match for Spurs since Jan Vertonghen in spring 2013.
Match summary
Micky Van de Ven heads into the net two times in opening period
Everton's Jake O'Brien has goal ruled after video check
Senegalese midfielder scores final goal in 89th minute
This loss is the Merseyside club's initial at Hill Dickinson Stadium
Micky van de Ven scored twice as Spurs extended their unbeaten run in away games in the Premier League and delivered the Toffees their first defeat at Hill Dickinson Stadium.
The Toffees were undefeated in their five previous fixtures at their recently opened stadium at Bramley-Moore Dock, having left their historic home behind after more than a century at the end of last season.
But Spurs captain Van de Ven pounced on two occasions from corners in the first half to put their impressive record at jeopardy, and they were unable to turn it around before the midfielder - assisted by ex-Everton forward Richarlison - nodded in a final goal to seal the victory.
Jake O'Brien thought he had equalized the tally five minutes after Van de Ven's opener, directing a bullet header past the Spurs keeper from an set-piece.
The Portuguese striker, in the meantime, missed a number of opportunities, while the Italian goalkeeper made a succession of excellent saves to guarantee the London club went five matches on the road unbeaten in the Premier League.
But the VAR stepped in, advising Craig Pawson to review the score on the pitchside monitor and the official ruled that the winger and the attacker were in an illegal position and had impeded with the Spurs keeper.
The win moves the manager's side up to third in the Premier League, five points off north London rivals and table-toppers the Gunners.
Everton remain 14th and are half a dozen points ahead of the relegation zone.
Tottenham analysis: Van de Ven excels in duties at each end of the field
After a uninspiring midweek display in the Champions League against the French side, where they mustered a mere two shots on goal, the manager opted for the French striker up front instead of former Toffees player the Brazilian.
The summer signing was failed to influence the game before being substituted for Richarlison after 60 minutes on the field, but it emerged he proved unnecessary in the final outcome.
Centre-back Van de Ven transformed into an attacking force to be feared.
Spurs' opening strike came from a well-worked set-piece play, with Rodrigo Bentancur heading the ball back across the six-yard box for an unmarked Van de Ven to head home.
And Ven de Ven - filling in as skipper in Cristian Romero's unavailability - added his next goal in first-half stoppage time as he outjumped the England keeper to nod in.
The Dutchman was just as impressive in defensive duties, combining effectively with Kevin Danso as the duo handled excellently with the 34 crosses thrown their way by Everton.
Everton analysis: Everton lacking finishing touch
Everton's recent stadium had been a happy hunting ground, but it seems the novelty may have faded slightly and supporters headed to the gates after the midfielder's third for Spurs.
The break in Everton's unbeaten home run won't be a massive concern for the manager, but their attacking woes will be.
The forward and Thierno Barry - the Everton's two recognised strikers - had scored just a single goal combined before Sunday's outing.
And they were failed to add to that miserable tally on a damp and dreary evening on Merseyside.
Beto's performance was summed up when he opted to bicycle-kick a clear chance from close range, even with having room and time to reposition for a simpler shot that would have tested the keeper.
The substitute, as well, failed to make an impact after replacing the starter in the second half.
It wasn't for a lack of opportunity. Most of Everton's attacks came through Grealish and the forward, who relentlessly delivered dangerous balls into the Tottenham box.
What next for both teams?
The Toffees: Moyes' men travel to Sunderland in the Premier League on Monday, 3 November at 20:00 GMT.
Spurs: Spurs go to Newcastle's ground on late October for their next round Carabao Cup match against the Magpies.